Remediation of prostrate-related disorders using polyphenols: kolaviron and quercetin in perspective

The study aimed to examine the effects of kolaviron and quercetin on testosterone-induced benign prostatic hyperplasia (BPH) in Wistar rats. Fifty rats weighing between 250g and 300g were selected, with forty-two rats being divided into six groups of seven each. The first group served as the control and received 0.5ml of Canola oil. The remaining groups were induced with BPH using a 5mg/kg body weight testosterone injection for four weeks. After BPH induction, the second group received 0.5ml of Canola oil, while the third, fourth, fifth, and sixth groups were treated with 150mg/kg body weight Kolaviron, 15mg/kg body weight Quercetin, 150mg/kg body weight Kolaviron combined with 15mg/kg body weight Quercetin, and 5mg/70kg body weight finasteride for twenty-eight days. BPH induction notably increased levels of various biomarkers such as malondialdehyde, total protein, albumin, globulin, total bilirubin, conjugated bilirubin, total cholesterol, triglycerides, LDL-c, and VLDL-c compared to the control group. However, treatment with Kolaviron and Quercetin effectively reversed these elevations. Notably, the Quercetin group did not exhibit significant differences in triglyceride levels compared to the BPH-induced group. BPH induction also led to a significant reduction in HDL-c levels compared to the control group, which was reversed by Kolaviron and Quercetin treatment. In conclusion, the findings suggest the potential of utilizing kolaviron and quercetin for the treatment of prostate-related conditions.