Biochemical investigation into the influence of telfairia occidentalis on hepatic oxidative stress markers and pro-inflammatory biomarkers induced by streptozotocin
Article Abstract
In rat models of diabetes, this research examined the biochemical impact of Telfairia occidentalis (TO) on pro-inflammatory biomarkers and hepatic oxidative stress markers caused by streptozotocin (STZ). There were five experimental groups: G 1 (Normal control) received 0.5 ml of distilled water; G 2 through 5 received 10% fructose for 14 days, after which STZ was administered intraperitoneally once. After the diagnosis of diabetes was confirmed, rats in groups 3 (TO1), 4 (TO2), and 5 (MET) were given 200 mg/kg b.w. TO, 300 mg/kg b.w. TO, and 300 mg/kg b.w. Metformin, respectively, for 28 days. The findings show that STZ significantly (p
Keywords
Diabetes mellitus
Telfairia occidentalis
antioxidant enzymes
inflammatory biomarkers.
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How to Cite this Article
Ujong U.P, Ogwoni H.A, Peter-Ujong V., Aja P.M. "Biochemical investigation into the influence of telfairia occidentalis on hepatic oxidative stress markers and pro-inflammatory biomarkers induced by streptozotocin." KIU Journal of Health Sciences , vol. 4 , no. 1 , 2024 , pp. 22-35