Anti-inflammatory effects of khaya senegalensis bark and tinospora cordifolia leaf extracts on striatal ischemic injury in rats

The striatal synaptic pathways play a crucial role in the functioning of the basal ganglia and are an essential part of the cortical-basal ganglia loops that regulate motor function, emotion, and cognition. The purpose of this study was to examine the potential therapeutic benefits of extracts from the leaves of Tinospora cordifolia (TC) and Khaya senegalensis (KS) on striatal ischemia injury resulting from amitriptyline (AMT). Eleven groups (n = 5) comprising fifty-five adult male Wistar rats weighing between 184 and 254 g were created: Distilled water (2 milliliters per kilogram) was used as a control. The groups that included AMT (750 mg/kg), KS (200 mg/kg) + AMT, KS (300 mg/kg) + AMT, KS (400 mg/kg) + AMT; TC (200 mg/kg) + AMT; TC (300 mg/kg) + AMT; TC (400 mg/kg) + AMT; COM (200 mg/kg) + AMT; COM (300 mg/kg) + AMT and COM (400 mg/kg) + AMT. Treatment was given orally for a period of 14 days. Rats were neck dislocated to stop the experiment and brain tissues were removed and preserved in 10% buffered formal saline. TNF- α result showed a significant increase (p